Defects in complement and "secondary" hemolytic uremic syndrome.

Timmermans, Sjoerd A M E G;Wérion, Alexis;Morelle, Johann;van Paassen, Pieter
(2019) Kidney International — Vol. 96, n° 2, p. 517 (2019)

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(en) The thrombotic microangiopathy syndromes are extraordinarily diverse. Most thrombotic microangiopathy syndromes, ∼90%, occur in the setting of coexisting diseases and have been termed secondary hemolytic uremic syndrome (HUS), while a subset of thrombotic microangiopathy syndromes occur on the background of complement gene variants and are termed primary atypical HUS. 1 Le Clech et al.2 recently reported the low prevalence of such variants in patients with secondary HUS and poor clinical outcomes. [...]
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Timmermans, S. A. M. E. G., Wérion, A., Morelle, J., & van Paassen, P. (2019). Defects in complement and “secondary” hemolytic uremic syndrome. Kidney International, 96(2), 517. https://doi.org/10.1016/j.kint.2019.04.011 (Original work published 2019)