The effect of membrane characteristics on tumour necrosis factor kinetics during haemodialysis.

Ghysen, J.;De Plaen, Jacques;Van Ypersele de Strihou, Charles
(1990) Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association — Vol. 5, n° 4, p. 270-274 (1990)

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  • Ghysen, J.
    Author
  • De Plaen, JacquesUCLouvain
    Author
  • Van Ypersele de Strihou, CharlesUCLouvain
    Author
Abstract
We measured serum beta 2-M and TNF alpha before and after a 4-h haemodialysis performed on two membranes with different characteristics, either cuprophane (n = 40) or polyacrylonitrile (AN69) (n = 31). Kinetic studies including determinations at 0, 15, 30, 60 and 240 min were also performed during haemodialysis sessions on cuprophane (n = 14) and AN69 (n = 12). After a 240-min haemodialysis, TNF alpha increased on cuprophane (21.95 +/- 3.46 to 37.20 +/- 4.60 pg/ml, P less than 0.001) but remained stable on AN69 (16.70 +/- 2.60 to 19.90 +/- 2.90 pg/ml, NS). Kinetic studies revealed that on cuprophane, beta 2-M increased progressively from 40.72 +/- 4.41 to 45.71 +/- 4.77 mg/l (P less than 0.001) at 240 min with a significant increase already noted at 60 min. TNF alpha remained stable during the first 60 min but increased significantly at 240 min (34.14 +/- 6.60 to 49.71 +/- 8.78 pg/ml, P less than 0.001). The percentage increment in TNF alpha (50.5%) was significantly greater at 240 min than the percentage increment in beta 2-M (13.4%), a finding suggestive of net generation of TNF alpha. On AN69, beta 2-M decreased progressively from 31.82 +/- 2.70 to 27.30 +/- 2.26 mg/l (P less than 0.001). TNF alpha decreased transiently at 15 min but returned subsequently to control values (0 and 240 min: 25.00 +/- 3.81 and 29.75 +/- 3.59 pg/ml respectively, NS). Our data suggest a net release of TNF alpha during cuprophane but not during polyacrylonitrile haemodialysis. This release might play a role in the stimulation of beta 2-M production and thus in the genesis of dialysis amyloidosis.
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Ghysen, J., De Plaen, J., & Van Ypersele de Strihou, C. (1990). The effect of membrane characteristics on tumour necrosis factor kinetics during haemodialysis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 5(4), 270-274. https://hdl.handle.net/2078.5/54007 (Original work published 1990)