Recurrent fulminant anti-glomerular basement membrane nephritis at a 7-year interval.

Fonck, C;Loute, G.;Cosyns, Jean-Pierre;Pirson, Yves
(1998) American Journal of Kidney Diseases — Vol. 32, n° 2, p. 323-327 (1998)

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Authors
  • Fonck, C
    Author
  • Loute, G.
    Author
  • Cosyns, Jean-PierreUCLouvain
    Author
  • Pirson, YvesUCLouvain
    Author
Abstract
True recurrence of anti-glomerular basement membrane (anti-GBM) nephritis is very rare, both in native kidneys and after renal transplantation. We report the recurrence of fulminant anti-GBM nephritis in a kidney graft recipient after the spontaneous withdrawal of immunosuppressive treatment more than 5 years after renal transplantation. The initial episode of anti-GBM nephritis had destroyed the native kidneys 7 years earlier. Circulating anti-GBM antibodies had disappeared for 14 months at the time of transplantation and reappeared with recurrence. This observation challenges the concept of anti-GBM nephritis as a single-shot illness and emphasises the need to consider the possibility of recurrence, even in the long term, among patients who underwent transplantation for anti-GBM nephritis.
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Fonck, C., Loute, G., Cosyns, J.-P., & Pirson, Y. (1998). Recurrent fulminant anti-glomerular basement membrane nephritis at a 7-year interval. American Journal of Kidney Diseases, 32(2), 323-327. https://doi.org/10.1053/ajkd.1998.v32.pm9708621 (Original work published 1998)