Green-synthesis of zinc oxide nanoparticles for the treatment of type 2 diabetes mellitus
(2024)
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- Authors
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- Abstract
- Type 2 diabetes mellitus (T2DM) is caused by insulin resistance, impaired insulin secretion or both. This thesis aims to develop a zinc supplement for diabetics based on zinc oxide nanoparticles (ZnONPs) and eventually combine them with lipid nanocapsules (LNCs) to increase insulin secretion, reduce insulin resistance and hyperglycemia. We synthesized ZnONPs using an aqueous extract of Panda oleosa, a plant with antidiabetic properties. These green-synthesized ZnONPs exhibited good properties (e.g., stability) and were able to lower blood glucose levels in vivo in diabetic mice better than marketed chemically-synthesized ones. This high activity was attributed to the contribution of phytocompounds present in green-synthesized ZnONPs. Their co-administration with LNCs did not show synergistic effects. In conclusion, this work has shown the benefit of green-synthesized ZnONPs over chemically-synthesized ones as a potential supplement in the treatment of DMT2.
- Affiliations
UCLouvain SSS/LDRI - Louvain Drug Research Institute
Citations
Kambale Kavungere, E. (2024). Green-synthesis of zinc oxide nanoparticles for the treatment of type 2 diabetes mellitus. https://hdl.handle.net/2078.5/215572