Diorganotin Derivatives of 2,6-dihydroxymethylpyridine and of 3-(n-pyrrolidino)-1,2-propanediol - Synthesis, Characterization and Invitro Antitumor-activity

Gielen, M.;Boualam, M.;Biesemans, M.;Mahieu, Bernard;Willem, R.
(1992) Heterocycles — Vol. 34, n° 3, p. 549-559 (1992)

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  • Gielen, M.
    Author
  • Boualam, M.
    Author
  • Biesemans, M.
    Author
  • Mahieu, BernardUCLouvain
    Author
  • Willem, R.
    Author
Abstract
Three diorganotin(IV) derivatives of 2, 6-dihydroxymethyl-pyridine and 3-(N-pyrrolidino)-1, 2-propanediol have been synthesized and characterized by Mossbauer spectroscopy, mass spectrometry and by H-1, C-13 and Sn-119 nmr. Their activities in vitro against two human tumor cell lines, MCF-7 and WiDr, are compared to those of cis-platin and doxorubicin.
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Gielen, M., Boualam, M., Biesemans, M., Mahieu, B., & Willem, R. (1992). Diorganotin Derivatives of 2,6-dihydroxymethylpyridine and of 3-(n-pyrrolidino)-1,2-propanediol - Synthesis, Characterization and Invitro Antitumor-activity. Heterocycles, 34(3), 549-559. https://doi.org/10.3987/COM-91-5944 (Original work published 1992)