Protein structure-based design of anti-protozoal drugs

Verlinde, Christophe LMJ.;Bressi, Jerome C;Choe, Jungwoo;Suresh, Stephen;Hol, Wim GJ.;et.al.
(2002) Brazilian Symposium on Medicinal Chemistry (BRAZMEDCHEM) — Location: CAXAMBU(Brazil) (11.November.2001)

Files

61635.pdf
  • Restricted Access
  • Adobe PDF
  • 733.66 KB
Request a copy

Details

Authors
  • Verlinde, Christophe LMJ.
    Author
  • Bressi, Jerome C
    Author
  • Choe, Jungwoo
    Author
  • Suresh, Stephen
    Author
  • Michels, Paul AM.UCLouvain
    Author
  • Hol, Wim GJ.
    Author
Show more
Abstract
The repertory of drugs to fight protozoal diseases such as malaria, Chagas' disease, leishmaniasis, and African trypanosomiasis is woefully inadequate. Now, genome sequencing and structural genomics projects are quickly elucidating new drug targets, providing incredible opportunities for medicinal chemists. Here, we illustrate the power of structure-based drug design in this process by our efforts to selectively block trypanosomal glycolysis.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Verlinde, C. LMJ., Bressi, J. C., Choe, J., Suresh, S., Buckner, F. S., Van Voorhis, W. C., Michels, P. AM., Gelb, M. H., & Hol, W. GJ. (2002). Protein structure-based design of anti-protozoal drugs. Journal of the Brazilian chemical society on-line, 13(6), 843-848. https://hdl.handle.net/2078.5/98619 (Original work published 2002)