Prefrontal cortex aspiration in pups and juvenile rats: behavioural changes and recovery of function.
(1989) Archives Internationales de Physiologie et de Biochimie — Vol. 97, n° 2, p. 163-174 (1989)
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- Male Wistar rats sustaining prefrontal cortex aspiration or sham operation at 6 days or 30 days of age were submitted to the following behavioural tests: open-field, acquisition and retention of two-way active as well as passive avoidance tasks. In the open-field the locomotor activity proved enhanced in all the aspirated animals and this enhancement lasted for 30 days. In the two-day active avoidance task, an acquisition deficit was observed in both aspirated groups; but when retrained one month later, they were able to acquire the avoidance task like sham-operated rats and no difference appeared between the groups aspirated at 6 or at 30 days of age. Concerning the passive avoidance task, no difference could be detected between aspirated and sham-operated animals of both groups except that the rats aspirated at an early age (6 days) seemed to display a better avoidance ability in the retention test. These behavioural alterations (hyperactivity and impairment of the acquisition of the 2-way active avoidance) resulted from the prefrontal cortex aspiration, at whatever age this aspiration was performed (6 days or 30 days). They disappeared after a postoperative recovery period of about one month, as evidenced by this longitudinal study.
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Gewiss, M., Eclancher, F., Poels, J. F., Van Boxel, P., & De Witte, P. (1989). Prefrontal cortex aspiration in pups and juvenile rats: behavioural changes and recovery of function. Archives Internationales de Physiologie et de Biochimie, 97(2), 163-174. https://hdl.handle.net/2078.5/42494 (Original work published 1989)