IRF4 mutations in chronic lymphocytic leukemia.
(2011) Blood — Vol. 118, n° 10, p. 2827-2829 (2011)
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- Abstract
- Interferon regulatory factor 4 (IRF4) is a member of the interferon regulatory factor family of transcription factors and has been shown to have critical functions at several stages of B-cell development. Genome-wide association study identified a polymorphism in the 3' untranslated region of IRF4 as a chronic lymphocytic leukemia risk locus. In this study, we report a recurrent heterozygous somatic mutation in the DNA-binding domain of IRF4 detected in 7 of 457 chronic lymphocytic leukemia patients (1.5%). Patients with IRF4 mutation have a good prognosis, and 4 of 6 have a trisomy 12. We also found that IRF4 mRNA expression is higher in the patients with the mutation.
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Citations
Havelange, V., Pekarsky, Y., Nakamura, T., Palamarchuk, A., Alder, H., Rassenti, L., Kipps, T., & Croce, C. M. (2011). IRF4 mutations in chronic lymphocytic leukemia. Blood, 118(10), 2827-2829. https://doi.org/10.1182/blood-2011-04-350579 (Original work published 2011)