Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality.
(2001) Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 9, n° 4, p. 1037-1044 (2001)
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- A series of 5-aryl- and 3,5-bis-aryl-2-amino-1,4-pyrazine derivatives 4 and 6, and related imidazolopyrazinones 7, has been synthesized, the aryl groups of which are catechol and/or phenol substituents. These compounds, tested against human keratinocyte cells stressed by UVB irradiation, showed high antioxidative properties. One compound (6f) was more active than EGCG/ECG (green tea extract) in reducing cell mortality.
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Cavalier, J. F., Burton, M., Dussart, F., Marchand, C., Rees, J.-F., & Marchand-Brynaert, J. (2001). Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality. Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, 9(4), 1037-1044. https://doi.org/10.1016/S0968-0896(00)00321-7 (Original work published 2001)