Organic electrochemistry applied to the Kolbe anodic cyclization of functionalized 2-pyrrolidinones
(2020)
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- Authors
- Supervisors
- Riant , Olivier
- Abstract
- The nootropic compounds are a group of pharmacologically active 2-pyrrolidinones. These molecules, enhancing cognition properties and possessing a large prescription field, are particularly interesting synthetic targets for the pharmaceutical industry. We envision the development of a novel pyrrolidinone synthesis by organic electrochemistry, using the mixed Kolbe electrolysis as our key-step. Our methodology is derived from the five-and six-membered-ring compounds synthesis developed previously in the research group of the prof. István Markó. The electrochemically based cyclization strategy includes a Kolbe decarboxylation, followed by an intramolecular radical cyclization and a radical-radical cross-coupling. Electrochemistry has been chosen since this technology is environmentally friendly, relatively inexpensive and easily transposed to batch reactors and continuous-flow systems. This synthesis would be an original and innovative approach to form therapeutically active molecules.
- Affiliations
Citations
Quertenmont, M. (2020). Organic electrochemistry applied to the Kolbe anodic cyclization of functionalized 2-pyrrolidinones. https://hdl.handle.net/2078.5/121482