Sharing of the Il-2 Receptor-gamma Chain With the Functional Il-9 Receptor Complex
(1995) International Immunology — Vol. 7, n° 1, p. 115-120 (1995)
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- Abstract
- The third subunit, the so-called common gamma (gamma(c)) chain, of the IL-2 receptor is shared among the receptors for IL-2, IL-4, IL-7 and IL-15, and dysfunction of the gamma(c) chain is thought to cause X-linked severe combined immunodeficiency (XSCID) ascribed to impairment of early T cell development. However, cytokines linked to XSCID are as yet unidentified. A mAb specific for the gamma(c) chain, TUGm2, profoundly inhibited cell proliferation in response to IL-9. Another mAb, TUGm3, immunoprecipitated [I-125]IL-9 cross-linked with either the IL-9 receptor or the gamma(c) chain. These results demonstrate that the gamma(c) chain is included in the functional receptor complex for IL-9, which was initially characterized as a T cell growth factor and is essential for IL-9-dependent growth signal transduction.
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Citations
Kimura, Y., Takeshita, T., Kondo, M., Ishii, N., Nakamura, M., Van Snick, J., & Sugamura, K. (1995). Sharing of the Il-2 Receptor-gamma Chain With the Functional Il-9 Receptor Complex. International Immunology, 7(1), 115-120. https://doi.org/10.1093/intimm/7.1.115 (Original work published 1995)