Distinct Role of FAK Kinase and C-Terminal Domains on Small-Cell Lung Cancer Proliferation [P3.15-004]
(2017) IASLC 18th World Conference on Lung Cancer — Location: (Japan) Yokohama (15.October.2017)
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- Abstract
- Small-cell lung cancer (SCLC) is a devastating illness with a median five-year overall survival of 5%. Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase which regulates integrin and growth factor signaling pathways involved in cell proliferation, survival, migration, and invasion. FAK is overexpressed/activated in many cancers, including SCLC. We hypothesized that FAK overexpression/activation in SCLC contributes to its aggressive behavior and that FAK may represent a novel therapeutic target in SCLC.
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Aboubakar Nana, F., Lecocq, M., Ladjemi, M., Detry, B., Dupasquier, S., Massion, P., Sibille, Y., Pilette, C., & Ocak, S. (2017). Distinct Role of FAK Kinase and C-Terminal Domains on Small-Cell Lung Cancer Proliferation [P3.15-004]. Journal of Thoracic Oncology, 12(11), S2339. https://doi.org/10.1016/j.jtho.2017.09.1794 (Original work published 2017)