Assembly of Discrete Aromatic Stacks through Complimentary Hydrogen Bonding with DNA/RNA Oligomers
(2018) Supr@lyon — Location: Lyon, France (12.December.2018)
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- Abstract
- Self-assembly in biological systems is essential in many necessary functions for life, including enzymatic catalysis, replication and production of DNA/RNA. Moreover, the ability to control the assembly of well-defined molecular building blocks in order to generate specific arrangements of functional groups has an important influence in areas from molecular recognition to material development, however generating the systems with precision in terms of both number and composition is a challenge. By contrast, the assembly of aromatic units to well-ordered structures through non-covalent interactions is ubiquitous in biological systems and gives rise to the variety of functions necessary for life. The best example is DNA and RNA, the specific hydrogen bonds between the base pairs G and C, A and T(U) in the nucleic acids give ordered aromatic structures forming the basis to store biological information. In this project, we aim to take advantage of the specific hydrogen bonding patterns occurring in nucleobases of DNA/RNA to promote the self-assembly of well-defined stacks of non-biological aromatic molecules. To accomplish this, we are synthesizing tritopic aromatic molecules functionalized with nucleobase units with the goal of studying their assembly in the presence of short complimentary single strands of DNA/RNA(Fig. 1).
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Xiao Mu, & Singleton, M. (2018). Assembly of Discrete Aromatic Stacks through Complimentary Hydrogen Bonding with DNA/RNA Oligomers. Supr@lyon, Lyon, France. https://hdl.handle.net/2078.5/104077