BACKGROUND: Osteosarcoma of the head and neck, especially primary forms, remains a rare and highly malignant tumor. PATIENTS: This report describes two patients who developed an osteosarcoma of the face more than ten years after treatment for bilateral retinoblastoma. We also report a third patient who presented with a primary osteosarcoma of the right superior maxilla which is one of the rarest tumors encountered in childhood oncology. CONCLUSIONS: The mainstay of therapy is surgical resection with negative margins. Careful, long-term follow-up of survivors of hereditary retinoblastoma is essential, especially for those given radiation therapy.
Maes, P., Brichard, B., Vermylen, C., Cornu, G., & Ninane, J. (1998). Primary and secondary osteosarcoma of the face: a rare childhood malignancy. Medical and Pediatric Oncology, 30(3), 170-174. https://doi.org/10.1002/(SICI)1096-911X(199803)30:3<170::AID-MPO8>3.0.CO;2-E (Original work published 1998)