Equilibrium of nucleotides in stimulated frog muscles
(1971) XXVth IUPS, vol. IX, p. 97. — Location: Munich
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- Authors
Maréchal, Georges 
- Abstract
- Creatine (C), phosphorylcreatine (PC), ATP, ADP, AMP and IMP have been assayed in perchloric acid extract of 144 frog sartorius muscles (half of them being poisoned with iodoacetate). The muscles have been frozen at the end of one isometric tetanus (20°C) before they could relax. The ratio C/PC increases with duration of stimulation, from 0.45 for resting muscle to 8.4 for iodoacetate poisoned muscles stimulated 12 sec. In a first approximation, the associated changes in ATP, ADP and AMP agree with a simple equilibrium model. When C/PC goes over 2, an IMP production occurs which is always higher than AMP production; this suggests that deamination of AMP stabilizes ATP at a level higher than that predicted by a simple equilibrium model.
Citations
Canfield, P., & Maréchal, G. (1971). Equilibrium of nucleotides in stimulated frog muscles. XXVth IUPS, vol. IX, p. 97., XXVth IUPS, vol. IX, p. 97. https://hdl.handle.net/2078.5/231272