One-pot synthesis and in vitro antitumor activity of some bipyrazolic tripodal derivatives

Radi, Smaail;Toubi , Yahya;Draoui, Nihed;Feron, Olivier;Riant, Olivier
(2012) Letters in Drug Design & Discovery — Vol. 9, n° 3, p. 305-309 (2012)

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The synthesis and structure-activity relationships (SAR) antitumor activities of monopyrazolic and bipyrazolic tripodal derivs. were reported here for the first time. The ten products were tested against three human cancer cell lines including breast (MDA-MB231), prostate (PC3) and colorectal (LoVo) cancers. In bipyrazolic series, most of them exhibited a moderate antitumor activity against three human cancer cell lines with an order of 5 > 7 > 8 in case of colorectal cancer and 5 > 7 ≈ 8 in case of breast and prostate cancers.
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Radi, S., Toubi, Y., Draoui, N., Feron, O., & Riant, O. (2012). One-pot synthesis and in vitro antitumor activity of some bipyrazolic tripodal derivatives. Letters in Drug Design & Discovery, 9(3), 305-309. https://doi.org/10.2174/157018012799129792 (Original work published 2012)