Cerebrovascular effect of calcium antagonists.
(1990) European Neurology — Vol. 30 Suppl 2, p. 10-5; discussion 39-41 (1990)
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- Activity of calcium antagonists was assessed in microvessels (internal diameter 5-50 microns) isolated from rat brain. High KCl solution induced an increase of the lanthanum-resistant 45Ca influx and a marked reduction in microvessel diameter. Both responses to depolarization were inhibited by the calcium antagonists nimodipine and flunarizine. Binding studies with 3H(+)PN200-110 used as a specific ligand of Ca channels revealed the existence of voltage-dependent, stereoselective binding sites for dihydropyridine calcium antagonists.
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Morel, N., & Godfraind, T. (1990). Cerebrovascular effect of calcium antagonists. European Neurology, 30 Suppl 2, 10-5; discussion 39-41. https://doi.org/10.1159/000117185 (Original work published 1990)