An elevated 1-h post- load glucose level during the oral glucose tolerance test detects prediabetes.
(2016) Diabetes & metabolic syndrome — Vol. 11, n° 2, p. 137-139 (2016)
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- The objective of the study was to compare the diagnosis of dysglycemic states by conventional oral glucose tolerance test (OGTT) criteria (fasting and 2-h plasma glucose) with the 1-h post-load plasma glucose level. 34 individuals (mean age: 55±13years; BMI: 27.7±6.3kg/m) at risk for prediabetes were administered a 75g OGTT. Individuals with normal glucose tolerance (NGT) or prediabetes were identified according to fasting and/or 2-h plasma glucose (PG) concentrations. Subsequently, subjects were divided in 2 groups: group 1 (n=21) with a 1-h PG<155mg/dl and group 2 (n=13) with a 1-h PG≥155mg/dl. HOMA was performed to assess β-cell function and insulin sensitivity. NGT or prediabetes based on conventional criteria correlated with the 1-h PG<or≥155mg/dl (p<0.001). Moreover, the 1-h PG≥155mg/dl was associated with higher HbA levels (6.1±0.5 vs. 5.5±0.3%, p<0.001) and significantly impaired insulin secretion and hyperbolic product (BxS) on HOMA test vs. 1-h PG<155mg/dl. The 1-h post-load plasma glucose value ≥155mg/dl is strongly associated with conventional criteria for (pre)diabetes and alterations of β-cell function.
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Buysschaert, M., Bergman, M., Yanogo, D., Jagannathan, R., Buysschaert, B., & Preumont, V. (2016). An elevated 1-h post- load glucose level during the oral glucose tolerance test detects prediabetes. Diabetes & metabolic syndrome, 11(2), 137-139. https://doi.org/10.1016/j.dsx.2016.12.002 (Original work published 2016)