Effects of creatine supplementation on healthy and pathological subjects
(2004)
Files
247893_Louis_These.pdf
Restricted Access - Adobe PDF
- 6.41 MB
Details
- Authors
- Supervisors
- Francaux, Marc
- Abstract
- Creatine is a derived nitrogenous amino acid distributed throughout the body with 95% found in skeletal muscle. In humans, oral creatine supplementation increases intramuscular total creatine content and enhances exercise performance. Moreover, muscle fibre size and body mass are increased. The purpose of this work was to investigate the physiological mechanisms of oral creatine supplementation in mature skeletal muscle, the potential benefit of this supplementation in myopathic patients, and the incidence of exogenous creatine on growing muscle cells. In human, at rest or after a resistance exercise, we were unable to detect any change in protein metabolism after 5 days of creatine supplementation, probably due to a detection threshold problem. However, the mRNA of IGF-I was increased after creatine supplementation, at rest and after exercise. In skeletal muscle culture cells, creatine induces a myotubes hypertrophy, associated with an increased protein and DNA content, as well as an increase in the mRNA of IGF-I. We observed an improvement in force and resistance to fatigue in patients suffering from Duchenne and Becker muscular dystrophy. An increase in the bone mineral density and a decrease in a bone resorption marker were also observed in ambulatory patients. Considering all our results, we can hypothesize that the IGF-I pathway is involved in the effects of creatine on bone an muscle function, in healthy and dystrophic subjects. Thus, if a creatine supplementation increases the IGF-I protein, it should be a very interesting adjuvant in clinical treatment for muscle wasting, and a useful additive treatment in neuromuscular disorders. ...
- Affiliations
Citations
Louis, M. (2004). Effects of creatine supplementation on healthy and pathological subjects. https://hdl.handle.net/2078.5/110755