FER and FES tyrosine kinase fusions in follicular T-cell lymphoma.
(2020) Blood — Vol. 135, n° 8, p. 584-588 (2020)
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- (en) TO THE EDITOR: Follicular T-cell lymphoma (FTCL) is a rare nodal mature T-cell neoplasm included in a broader category of angioimmunoblastic T-cell lymphoma (AITL) and other nodal lymphomas of T follicular helper (TFH) cell origin by the 2017 World Health Organization classification of tumors of hematopoietic and lymphoid tissues.1 The atypical, clear, medium-size neoplastic cells display a common TFH phenotype with expression of CD4, CD10, BCL6, PD-1, CXCL13, and ICOS.2 In contrast to AITL, FTCL is characterized by a follicular growth pattern and lacks the proliferation of high endothelial venules and the extrafollicular expansion of follicular dendritic cells. The molecular pathology of FTCL remains incompletely understood. Up to 40% of FTCLs harbor t(5;9)(q33.3;q22.2) fusing the N-terminal part of the interleukin-2 (IL-2)–inducible T-cell kinase (ITK) to the tyrosine kinase domain of SYK (the spleen tyrosine kinase). [...]
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Debackere, K., van der Krogt, J.-A., Tousseyn, T., Finalet Ferreiro, J. A., Van Roosbroeck, K., Marcelis, L., Graux, C., Dierickx, D., Ameye, G., Vandenberghe, P., Michaux, L. M., Cools, J., & Wlodarska, I. (2020). FER and FES tyrosine kinase fusions in follicular T-cell lymphoma. Blood, 135(8), 584-588. https://doi.org/10.1182/blood.2019002401 (Original work published 2020)