Identification of novel Reelin-regulated proteins important for Golgi dynamics during neuronal migration and dendrite morphogenesis in the developing neocortex
(2023)
Files
ThesismanuscriptECJ-2023.pdf
Closed Access - Adobe PDF
- 8.27 MB
Details
- Authors
- Supervisors
- Jossin, Yves
- Abstract
- During the formation of the 6-layered structure of the cerebral neocortex, excitatory neurons originate in the ventricular zone and migrate to the cortical plate where they complete their maturation. Golgi localization is crucial for neuronal migration, axon specification, and dendrite development. Reelin, one of the major signals regulating brain development, controls Golgi orientation during multipolar migration and induces Golgi translocation in the main apical dendrite after completion of migration. In this work, we show the requirement of the Golgi structural proteins, GRASP65 and GRASP55, for the multipolar migration and dendrite morphogenesis of cortical excitatory neurons. GRASP65 protein level is controlled by Reelin, and its accumulation is important for dendritic Golgi translocation and secretion of Fbxo45, a protein involved in cortical formation.
- Affiliations
Citations
Calvo Jimenez, E. (2023). Identification of novel Reelin-regulated proteins important for Golgi dynamics during neuronal migration and dendrite morphogenesis in the developing neocortex. https://hdl.handle.net/2078.5/27589