Antibody-independent thrombocytopenia in lactate dehydrogenase-elevating virus-infected mice.

Su, Dan;Musaji, Andrei;Legrain, Sarah;Detalle, Laurent;Coutelier, Jean-Paul;et.al.
(2012) Journal of Virology — Vol. 86, n° 22, p. 12414-12416 (2012)

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Authors
  • Su, Dan
    Author
  • Musaji, Andrei
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  • Legrain, Sarah
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  • Detalle, Laurent
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  • Coutelier, Jean-Paulorcid-logoUCLouvain
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Abstract
Previously we demonstrated that antibody-mediated thrombocytopenia is strongly enhanced by lactate dehydrogenase-elevating virus (LDV) infection. Here we report that mice infected with LDV develop a moderate thrombocytopenia, even in the absence of immunoglobulins or Fc receptors. A similar decrease of platelet counts was observed after mouse hepatitis virus infection. LDV-induced type I interferon-independent thrombocytopenia was partly suppressed by treatment with clodronate-containing liposomes. Therefore, we conclude that the thrombocytopenia results from increased phagocytosis of nonopsonized platelets by macrophages.
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Su, D., Musaji, A., Legrain, S., Detalle, L., van der Kaa, J., Verbeek, J. S., Ryffel, B., & Coutelier, J.-P. (2012). Antibody-independent thrombocytopenia in lactate dehydrogenase-elevating virus-infected mice. Journal of Virology, 86(22), 12414-12416. https://doi.org/10.1128/JVI.00745-12 (Original work published 2012)