Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro.
(1994) Planta Medica : natural products and medicinal plant research — Vol. 60, n° 1, p. 45-49 (1994)
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- Abstract
- In this work, we have analysed the effects of alpha-hederin, a monodesmosidic triterpenoid saponin isolated from Hedera helix, on mouse B16 melanoma cells and non-cancer mouse 3T3 fibroblasts cultured in vitro. Our results indicate that, in a serum-free medium, alpha-hederin is cytotoxic and inhibits proliferation in both cell lines at rather low concentrations (< 5 micrograms/ml) after only 8 hours of treatment. Its cytotoxicity decreases in the presence of serum in which BSA seems to be able to bind the saponin. alpha-Hederin also induces vacuolization of the cytoplasm and membrane alterations leading to cell death.
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Danloy, S., Quetin-Leclercq, J., Coucke, P., De Pauw-Gillet, M.-C., Elias, R., Balansard, G., Angenot, L., & Bassleer, R. (1994). Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro. Planta Medica : natural products and medicinal plant research, 60(1), 45-49. https://doi.org/10.1055/s-2006-959406 (Original work published 1994)