Differential-effects of Cerulein and Bombesin On the Ethanol Intake in the Rat
(1991) Archives Internationales de Physiologie et de Biochimie — Vol. 99, n° 2, p. 151-153 (1991)
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- Male Wistar rats were allowed to drink either water or water mixed with ethyl alcohol (4%, 8% and 12%) as part of a water-deprived procedure. The decapeptide caerulein (1,3 and 6-mu-g/kg i.p.), a cholecystokinin analog, decreased the intake of ethanol while the consumption of tap water remained unchanged in a choice paradigm. The addition of quinine (a bitter substance) in drinking bottles did not significantly modify the fluid consumption while the i.p. injection of caerulein produced a significant decrease in the consumption of the saccharin containing bottle. The i.p. administration of bombesin (10 and 20-mu-g/kg) failed to modify the intake of water or ethanol solution in water-deprived animals. Interpretations are given in terms of the action of the cholecystokinin analog on differences in the taste intensity induced by the beverage or in terms of a direct consequence of the caerulein-induced decreased gastric emptying effect leading to an accumulation of ethanol in the gut.
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Gewiss, M., Heidbreder, C., & De Witte, P. (1991). Differential-effects of Cerulein and Bombesin On the Ethanol Intake in the Rat. Archives Internationales de Physiologie et de Biochimie, 99(2), 151-153. https://doi.org/10.3109/13813459109146955 (Original work published 1991)