Substitution of 11C-methionine PET by perfusion MRI during the follow-up of treated high-grade gliomas: Preliminary results in clinical practice.
(2009) Journal of Neuroradiology — Vol. 37, n° 2, p. 89-97 (2010)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- PURPOSE: Our aim was to compare perfusion magnetic resonance imaging (MRI) and positron emission tomography (PET) using carbon-11 labelled methionine (MET) in gliomas and their value in differentiating tumour recurrence from necrosis. MATERIALS AND METHODS: We retrospectively reviewed 28 patients with a high-grade glioma. A total of 33MR perfusions and MET-PET were ultimately analysable for comparison between the relative cerebral blood volume (rCBV) and MET-PET examinations. Intra- and interobserver reproducibility was assessed and diagnostic value of rCBV compared to MET-PET and histology was assessed by the area under the receiver operating characteristic (ROC) curve. RESULTS: ROC curve analysis showed that rCBV had at least equal performances in differentiating tumour recurrence and necrosis than MET-PET. Cut-off value of rCBV for differentiating tumour from necrosis was 182% with a sensitivity of 81.5% and a specificity of 100%. CONCLUSION: In clinical practice, perfusion MRI could replace MET-PET for differentiating necrosis from tumour recurrence.
- Affiliations
Citations
Dandois, V., Rommel, D., Renard, L., Jamart, J., & Cosnard, G. (2009). Substitution of 11C-methionine PET by perfusion MRI during the follow-up of treated high-grade gliomas: Preliminary results in clinical practice. Journal of Neuroradiology, 37(2), 89-97. https://doi.org/10.1016/j.neurad.2009.04.005 (Original work published 2010)