[Mechanisms of Hypergastrinemia in Pernicious-anemia and Helicobacter-pylori Infection]
(1993) Acta Gastro-Enterologica Belgica (Multilingual Edition) — Vol. 56, n° 3-4, p. 245-250 (1993)
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- Abstract
- The authors review recent progresses made in the understanding of the disturbed gastrin homeostasis in Helicobacter pylori infection and in pernicious anaemia. Regulation of gastrin release is a complex mechanism involving inhibition by a low gastric pH and several peptides including somatostatin, and stimulation by different factors, mainly alimentary peptides and amino-acids. The hypergastrinaemia observed in patients with Helicobacter pylori infection occurs despite a normal intraluminal pH. This may be through alcalinisation of the gastric mucus layer due to the production of ammonia by the bacterial urease or through local release of inflammatory mediators. In pernicious anaemia a factor present in the anacid gastric juice could explain the important hypergastrinaemia observed. The gastrin releasing activity of the gastric juice itself was demonstrated by a decrease of the patients' plasma gastrin concentration during a neutral gastric lavage and by a rise of the gastrin levels in rats whose stomachs were perfused with gastric juice from pernicious anaemia patients. A better understanding of the relation between gastric pH and gastrin release is important not only for these pathological states but also for treatments which suppress acid secretion.
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Deprez, P., & Calam, J. (1993). [Mechanisms of Hypergastrinemia in Pernicious-anemia and Helicobacter-pylori Infection]. Acta Gastro-Enterologica Belgica (Multilingual Edition), 56(3-4), 245-250. https://hdl.handle.net/2078.5/146637 (Original work published 1993)