Role of the thymus in transplantation tolerance in miniature swine. III. Surgical manipulation of the thymus interferes with stable induction of tolerance to class I-mismatched renal allografts.

Yamada, K;Ierino, F L;Gianello, Pierre;Shimizu, A;Sachs, D H;et.al.
(1999) Transplantation — Vol. 67, n° 8, p. 1112-1119 (1999)

Files

Yamada-1999-IIIRoleofthethymus.pdf
  • Restricted Access
  • Adobe PDF
  • 4.73 MB
Request a copy

Details

Authors
  • Yamada, K
    Author
  • Ierino, F L
    Author
  • Gianello, PierreUCLouvain
    Author
  • Shimizu, A
    Author
  • Sachs, D H
    Author
Show more
Abstract
Previous studies have demonstrated that long-term tolerance of class I mismatched renal allografts in miniature swine is induced by a short course of cyclosporine (CyA), and that a total thymectomy 21 days before transplantation abrogates the induction of stable tolerance. We have now examined the effects of surgical manipulation of the thymus, with or without a reduction in the thymic volume, on the induction of tolerance.
Affiliations
  • Harvard Medical SchoolTransplantation biology research center, MGH, Boston

Citations

  • APA
  • Chicago
  • FWB

Yamada, K., Ierino, F. L., Gianello, P., Shimizu, A., Colvin, R. B., & Sachs, D. H. (1999). Role of the thymus in transplantation tolerance in miniature swine. III. Surgical manipulation of the thymus interferes with stable induction of tolerance to class I-mismatched renal allografts. Transplantation, 67(8), 1112-1119. https://hdl.handle.net/2078.5/35014 (Original work published 1999)