Sprint interval training in hypoxia stimulates glycolytic enzyme activity
(2013) Medicine and Science in Sports and Exercise — Vol. 45, n° 11, p. 2166-2174 (2013)
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- PURPOSE: In this study, we compared the effect of sprint interval training (SIT) in normoxia versus hypoxia on muscle glycolytic and oxidative capacity, monocarboxylate transporter content, and endurance exercise performance. METHODS: Healthy male volunteers (18-30 yr) performed 6 wk of SIT on a cycling ergometer (30-s sprints vs 4.5-min rest intervals; 3 d·wk<sup>-1</sup>) in either normobaric hypoxia (HYP, FiO<inf>2</inf> = 14.4%, n = 10) or normoxia (NOR, FiO<inf>2</inf> = 20.9%, n = 9). The control group did not train (CON, n = 10). Training load was increased from four sprints per session in week 1 to nine sprints in week 6. Before and after SIT, subjects performed a maximal incremental exercise test plus a 10-min simulated time trial on a cycle ergometer in both normoxia (MAX<inf>nor</inf> and TT<inf>nor</inf>) and hypoxia (MAX<inf>hyp</inf> and TT<inf>hyp</inf>). A needle biopsy was taken from musculus vastus lateralis at rest 5-6 d after the last exercise session. RESULTS: SIT increased muscle phosphofructokinase activity more in HYP (+59%, P < 0.05) than that in NOR (+17%), whereas citrate synthase activity was similar between groups. Compared with the pretest, power outputs corresponding to 4 mmol blood lactate in HYP during MAX<inf>nor</inf> (+7%) and MAX <inf>hyp</inf> (+9%) were slightly increased (P < 0.05), whereas values were constant in NOR. V̇O<inf>2max</inf> in MAX<inf>nor</inf> and TT performance in TT<inf>nor</inf> and TT<inf>hyp</inf> were increased by ∼6%-8% (P < 0.05) in either group. The training elevated monocarboxylate transporter 1 protein content by ∼70% (P < 0.05). In CON, all measurements were constant throughout the study. CONCLUSION: SIT in hypoxia up-regulated muscle phosphofructokinase activity and the anaerobic threshold more than SIT in normoxia but did not enhance endurance exercise performance. Copyright © 2013 by the American College of Sports Medicine.
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Puype, J., Van Proeyen, K., Raymackers, J.-M., Deldicque, L., & Hespel, P. (2013). Sprint interval training in hypoxia stimulates glycolytic enzyme activity. Medicine and Science in Sports and Exercise, 45(11), 2166-2174. https://doi.org/10.1249/MSS.0b013e31829734ae (Original work published 2013)