Implications of the miR-10 family in chemotherapy response of NPM1 mutated AML
(2014) Blood — Vol. 123, n° 15, p. 2412-2415 (2014)
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- Abstract
- Nucleophosmin mutated AML (NPM1mut-AML) patients have a high rate of complete remission (CR) to induction chemotherapy. However, the mechanisms responsible for such effects are unknown. Since miR-10 family members are expressed at high levels in NPM1mut-AML, we evaluated whether these microRNAs could predict chemotherapy response in AML. We found that high baseline miR-10 family expression in 54 untreated cytogenetically heterogeneous AML patients was associated with achieving CR. However, when we included NPM1 mutation status in the multivariable model, there was a significant interaction effect between miR-10a-5p expression and NPM1 mutation status. Similar results were observed when using a second cohort of 183 cytogenetically normal older (age≥60 years) AML patients. Loss and gain of function experiments using miR-10a-5p in cell lines and primary blasts did not demonstrate any effect in apoptosis or cell proliferation at baseline or after chemotherapy. These data support a bystander role for the miR-10 family in NPM1mut-AML. only.
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Havelange, V., Ranganathan, P., Geyer, S., Nicolet, D., Huang, X., Yu, X., Volinia, S., Kornblau, S. M., Andreeff, M., Croce, C. M., Marcucci, G., Bloomfield, C. D., Garzon, R., & et al. (2014). Implications of the miR-10 family in chemotherapy response of NPM1 mutated AML. Blood, 123(15), 2412-2415. https://doi.org/10.1182/blood-2013-10-532374 (Original work published 2014)