Don't let D-dimer fool you: Elevated D-dimer plasma levels should not imply 'hyperfibrinolysis'.

Hardy, Michaël;Bareille, Marion;Lecompte, Thomas;Mullier, François
(2022) Thrombosis research — Vol. 214, p. 63-64 (2022)

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(en) DEAR EDITOR, We read with interest the letter by Nielsen N.D. and coll. [1] dealing with D-dimer and fibrinolysis in COVID-19 patients. The authors discussed the apparent discrepancy between increased D-dimer in and decreased fibrinolysis potential of the blood of COVID-19 patients. They proposed an extravascular origin for the observed increase in D-dimer plasma levels, which could solve the so-called paradox. This interesting discussion provides us with an opportunity to highlight some key points about D-dimer and the methods used to assess fibrinolysis. [...]
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Hardy, M., Bareille, M., Lecompte, T., & Mullier, F. (2022). Don’t let D-dimer fool you: Elevated D-dimer plasma levels should not imply ‘hyperfibrinolysis’. Thrombosis research, 214, 63-64. https://doi.org/10.1016/j.thromres.2022.04.012 (Original work published 2022)