Organotin(iv) Compounds of 2-thiopyridine - Crystal and Molecular-structure of Dicyclohexyltin(iv) Bis(2-pyridylthiolate)
(1992) Inorganica Chimica Acta — Vol. 200, p. 249-255 (1992)
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- Abstract
- Dicyclohexyltin(IV) bis(2-pyridylthiolate), compound 1, crystallizes in the orthorhombic system, a = 16.448(3), b = 40.315(8) and c = 7.113(3). Its molecular structure is best described as a tetrahedron, based on the two carbon-tin and the two sulfur-tin bonds, which is however strongly distorted as a consequence of two weak additional nitrogen-tin bonds. Compound 1 and four other diorganotin(IV) bis(2-pyridylthiolates) are characterized by Mossbauer, H-1, C-13 and Sn-119 NMR spectroscopy, and by FAB mass spectrometry. Their in vitro antitumour activity against two human tumour cell lines, MCF-7 and WiDr is reported. The ID50 values found are comparable to those found for cis-platin, but deceptively higher than for many other diorganotin compounds.
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Citations
Boualam, M., Meunierpiret, J., Biesemans, M., Willem, R., & Gielen, M. (1992). Organotin(iv) Compounds of 2-thiopyridine - Crystal and Molecular-structure of Dicyclohexyltin(iv) Bis(2-pyridylthiolate). Inorganica Chimica Acta, 200, 249-255. https://doi.org/10.1016/S0020-1693(00)92367-3 (Original work published 1992)