Novel muscular anti-inflammatory mechanisms of adiponectin and their implication in Duchenne Muscular Dystrophy
(2017)
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- Authors
- Supervisors
- Brichard, Sonia
- Abstract
- Adiponectin (ApN), which is decreased in the metabolic syndrome, is a hormone that has antidiabetic properties by acting on various organs. In skeletal muscle, ApN reduces inflammation and oxidative stress caused by various stimuli (LPS, obesogenic diet) or by the absence of dystrophin. In this work, we investigated the anti-inflammatory mechanisms of ApN in skeletal muscle and their implication in Duchenne muscular dystrophy. On one hand, we have characterized microRNAs regulated by this hormone and, on the other hand, studied the role of the NLRP3 inflammasome complex in the development of chronic inflammation that characterizes dystrophic muscles.
- Affiliations
Citations
Boursereau, R. (2017). Novel muscular anti-inflammatory mechanisms of adiponectin and their implication in Duchenne Muscular Dystrophy. https://hdl.handle.net/2078.5/39367