The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery.

Ahlers, Sabine J G M;Elens, Laure;van Gulik, Laura;van Schaik, Ron H;Knibbe, Catherijne A J;et.al.
(2013) British Journal of Clinical Pharmacology —

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Authors
  • Ahlers, Sabine J G M
    Author
  • Elens, LaureUCLouvain
    Author
  • van Gulik, Laura
    Author
  • van Schaik, Ron H
    Author
  • Knibbe, Catherijne A J
    Author
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Abstract
The catechol-O-methyltransferase (COMT) Val158Met polymorphism affected pain sensitivity of healthy volunteers upon application of experimental pain stimuli. The relevance of these findings in morphine-treated postoperative cardiac patients undergoing painful healthcare procedures is unknown; therefore, the aim of this study was to investigate whether the COMT Val158Met polymorphism increases pain sensitivity in morphine-treated patients undergoing an unavoidable painful routine procedure after cardiac surgery.
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Ahlers, S. J. G. M., Elens, L., van Gulik, L., van Schaik, R. H., van Dongen, E. P. A., Bruins, P., Tibboel, D., & Knibbe, C. A. J. (2013). The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery. British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.12052