Copper Metallogel as Potential Drug Carrier for Anti‐Inflammatory Drugs

Choudhary, Priyanka;Gaur, Ruchi;Darsi Rambabu;Dhir, Abhimanew;Pooja;et.al.
(2021) ChemistrySelect — Vol. 6, n° 34, p. 9139-9143 (2021)

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Authors
  • Choudhary, Priyanka
    Author
  • Gaur, Ruchi
    Author
  • Darsi Rambabuorcid-logoUCLouvain
    Author
  • Dhir, Abhimanew
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  • Pooja
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Abstract
Copper based Metal-Organic Gels (MOGs) were evaluated for their efficiency as drug carrier for four anti-inflammatory drugs viz. 5-Fluorouracil (5FU), Phenidone (PN), Ibuprofen (IBP) and Cisplatin (CP). Copper(II)-benzene tricarboxylic acid (CuBTC) was used as a precursor for the loading and releasing of these drugs. The distinctive porous nature of the gel provided the high loading efficiency for these anti-inflammatory drugs. Among all the drugs evaluated, CuBTC@5FU exhibited maximum drug loading (88.1 %) and releasing (95 %) efficiency at physiological pH 5.2, which was attributed to the strong hydrogen bonding interactions between CuBTC and fluoride of 5FU.
Affiliations
  • Indian institute of Technology MandiIndia

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Choudhary, P., Gaur, R., Darsi Rambabu, Dhir, A., Gupta, A., & Pooja. (2021). Copper Metallogel as Potential Drug Carrier for Anti‐Inflammatory Drugs. ChemistrySelect, 6(34), 9139-9143. https://doi.org/10.1002/slct.202102490 (Original work published 2021)