The economics of temozolomide in brain cancer.
(2007) Expert Opinion on Pharmacotherapy — Vol. 8, n° 12, p. 1923-1929 (2007)
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- Abstract
- For 30 years, nitrosourea was the only adjuvant treatment available for aggressive glioma patients, despite its severe side effects; and, therefore, radiotherapy was often the therapy of choice. Survival prospect in these patients was, however, low with generally few patients surviving beyond 2 years. Recently, temozolomide was successfully tested in a number of randomised clinical trials and showed an increased survival. As many countries are considering reimbursement or have granted a market authorisation for temozolomide, a number of studies have been published in various countries in order to assess the cost-effectiveness of temozolomide for glioma patients in first- or second-line treatment. These studies show that in general, the incremental cost-effectiveness of temozolomide as adjuvant treatment, albeit at the higher end of commonly accepted thresholds, falls in line with other accepted cancer treatments.
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Crott, R. (2007). The economics of temozolomide in brain cancer. Expert Opinion on Pharmacotherapy, 8(12), 1923-1929. https://doi.org/10.1517/14656566.8.12.1923 (Original work published 2007)