Paving the way for a therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide

Porporato, Paolo;Sonveaux, Pierre
(2014) Molecular & Cellular Oncology — Vol. 2, n° 3, p. e968043 (2014)

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Abstract
Metastatic dissemination is of poor prognosis for cancer patients. When exploring glucose metabolism in metastatic progenitor cells, we recently found that several different dysfunctions sharing the ability of inducing mitochondrial superoxide production also promote tumor metastasis. Selective targeting of mitochondrial superoxide prevented spontaneous metastasis in mice, opening a new avenue for therapy.
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Porporato, P., & Sonveaux, P. (2014). Paving the way for a therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide. Molecular & Cellular Oncology, 2(3), e968043. https://doi.org/10.4161/23723548.2014.968043 (Original work published 2014)