Ionic cocrystals of etiracetam and levetiracetam: the importance of chirality for ionic cocrystals

Song, Lixing;Shemchuk, Oleksii;Robeyns, Koen;Dario Braga;Leyssens, Tom;et.al.
(2019) Crystal Growth & Design — Vol. 19, p. 2446-2454 (2019)

Files

Lixingsong_etal_ioniccocrystals-CrystalGrowthandDesign2019.pdf
  • Open Access
  • Adobe PDF
  • 2.33 MB
Download

Details

Authors
  • Song, LixingUCLouvain
    Author
  • Shemchuk, OleksiiUCLouvain
    Author
  • Robeyns, KoenUCLouvain
    Author
  • Dario BragaUniversita di Bologna (I)
    Author
  • Leyssens, TomUCLouvain
    Author
Show more
Abstract
A striking variety of anhydrous and hydrated ionic cocrystals (ICCs) of the enantiopure anti-epileptic drug (AED) levetiracetam and of its racemic intermediate etiracetam with the pharmaceutically acceptable salts CaCl2 and MgCl2 was synthesized and structurally characterized. The difference in the interaction of enantiopure and racemic compounds of interest with the inorganic salts was investigated. Variable temperature X-ray powder diffraction (VT XRPD) and calorimetric analyses (TGA and DSC) of all obtained ICCs showed a significant improvement in thermal stability with respect to pure racetams.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Song, L., Shemchuk, O., Robeyns, K., Dario Braga, Fabrizia Grepioni, & Leyssens, T. (2019). Ionic cocrystals of etiracetam and levetiracetam: the importance of chirality for ionic cocrystals. Crystal Growth & Design, 19, 2446-2454. https://hdl.handle.net/2078.5/59014 (Original work published 2019)