An E2F-dependent late-serum-response promoter in a gene that controls glycolysis.
(1995) Oncogene : including Oncogene Reviews — Vol. 11, n° 8, p. 1509-1517 (1995)
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- Abstract
- The F-type mRNA of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is found in proliferating, but not in quiescent, cells. This bifunctional enzyme catalyses the synthesis and degradation of fructose-2,6-bisphosphate, a potent stimulator of glycolysis. F-type mRNA concentration decreased upon differentiation of rat rhabdomyosarcoma cells; it increased in Rat-1 fibroblasts stimulated to proliferate by serum, by epidermal growth factor, or by the v-src oncogene product. This increase resulted, at least in part, from a stimulation of F promoter activity. The stimulation occurred at the G1/S transition of the cell cycle. It depended on a binding site for the oncogenic transcription factor E2F located in the first exon of F-type mRNA. This effect was inhibited by agents that increase cAMP concentration. The data provide the first evidence that a gene involved in the control of glycolysis can be regulated by a late-serum-response promoter in an E2F-dependent way.
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Darville, M. I., Antoine, I. V., Mertens-Strijthagen, J. R., Dupriez, V. J., & Rousseau, G. (1995). An E2F-dependent late-serum-response promoter in a gene that controls glycolysis. Oncogene : including Oncogene Reviews, 11(8), 1509-1517. https://hdl.handle.net/2078.5/67127 (Original work published 1995)