(en) From the Authors: We thank Dr. Upham for his interest and comments on our article about pIgR/SC (polymeric immunoglobulin receptor/secretory component) in asthma (1). First, although our data indeed show that bronchoepithelial pIgR immunostaining is reduced in asthma, irrespective of severity or its allergic phenotype, gene expression (pIgR mRNA levels) was not significantly affected. [...]
Ladjemi, M. Z., Gras, D., Gohy, S., Chanez, P., & Pilette, C. (2018). Reply to Upham: The Bronchial Epithelial Secretory IgA System in Asthma. American Journal of Respiratory and Critical Care Medicine, 198(9), 1236-1238. https://doi.org/10.1164/rccm.201806-1128LE (Original work published 2018)