GnRH Antagonist: a New and an Effective Way of Treatment of Advanced Prostate Cancer

Tombal, Bertrand;Raghunath, S Krishnappa;Srivatsa, Narasimha;Nagaraj, V.H
(2017) Indian Journal of Surgical Oncology — Vol. 8, n° 3, p. 385-388 (2017)

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Authors
  • Tombal, Bertrandorcid-logoUCLouvain
    Author
  • Raghunath, S Krishnappa
    Author
  • Srivatsa, Narasimha
    Author
  • Nagaraj, V.H
    Author
Abstract
Castration remains the mainstay of treatment in the management of metastatic prostate cancer. Medical castration plays an important role in a majority of these patients. Gonadotropin releasing hormone (GnRH) agonists have been commonly used hitherto to achieve medical castration. Arrival of GnRH antagonists have opened a new approach in the management of these patients with distinct drug-related and cancer-related benefits including prevention of microsurges and reduction in cardiovascular complications. This article elucidates the mechanism of action of GnRH antagonists along with its clinical advantages and demerits.
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Tombal, B., Raghunath, S. K., Srivatsa, N., & Nagaraj, V. H. (2017). GnRH Antagonist: a New and an Effective Way of Treatment of Advanced Prostate Cancer. Indian Journal of Surgical Oncology, 8(3), 385-388. https://doi.org/10.1007/s13193-016-0611-4 (Original work published 2017)