Alterations of the microcirculation are common in critically ill patients and persistence of these alterations is associated with poor outcome. Infusion of high doses of activated protein C can ameliorate the microcirculation. Because red blood cells (RBCs) play an essential role in oxygen transport to the tissues, we studied the effects of activated protein C on RBC deformability in septic patients.
Piagnerelli, M., Njimi, H., Coelho, T. V., Reggiori, G., Castanares Zapatero, D., Donadello, K., & Vincent, J.-L. (2013). Limited effects of activated protein C on red blood cell deformability. Clinical hemorheology and microcirculation, 53(4), 387-391. https://doi.org/10.3233/CH-2012-1550 (Original work published 2013)