A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.
(2005) Nature Genetics — Vol. 37, n° 6, p. 590-592 (2005)
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- Abstract
- We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
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Citations
Stephens, P., Edkins, S., Davies, H., Greenman, C., Cox, C., Hunter, C., Bignell, G., Teague, J., Smith, R., Stevens, C., O’Meara, S., Parker, A., Tarpey, P., Avis, T., Barthorpe, A., Brackenbury, L., Buck, G., Butler, A., Clements, J., et al. (2005). A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nature Genetics, 37(6), 590-592. https://doi.org/10.1038/ng1571 (Original work published 2005)