Small for size syndrome (SFSS) and hypoxia: lessons learned from the associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure in rats

Dili, Alexandra;Lebrun, Valérie;Claude, Bertrand;Leclercq, Isabelle
(2019) HPB : the official journal of the International Hepato Pancreato Biliary Association — Vol. 20, n° Suppl 2, p. S448-S449 (2019)

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(en) Excessive portal hypertension with compensatory arterial constriction of the future liver remnant (FLR) is considered the main cause of SFSS after major hepatectomy. ALPPS combines portal vein ligation and parenchymal transection to obtain rapid hypertrophy of FLR for patients needing marginal hepatectomy, with high risk of postoperative SFSS. This procedure sets the FLR in the same hemodynamic portal conditions as in SFSS, and yet, patients survive, and obtain boosted FLR hypertrophy. [...]
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Dili, A., Lebrun, V., Claude, B., & Leclercq, I. (2019). Small for size syndrome (SFSS) and hypoxia: lessons learned from the associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure in rats. HPB : the official journal of the International Hepato Pancreato Biliary Association, 20(Suppl 2), S448-S449. https://doi.org/10.1016/j.hpb.2018.06.2848 (Original work published 2019)