Diorganotin Difluorobenzoates - Synthesis, Spectroscopic Characterization and In-vitro Antitumor-activity - X-ray Structure Determination of Bis[di-n-butyl(2,6-difluorobenzoato)tin] Oxide

Gielen, M.;Biesemans, M.;Elkhloufi, A.;Meunierpiret, J.;Willem, R.;et.al.
(1993) Journal of Fluorine Chemistry — Vol. 64, n° 3, p. 279-291 (1993)

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Authors
  • Gielen, M.
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  • Biesemans, M.
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  • Elkhloufi, A.
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  • Meunierpiret, J.
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  • Willem, R.
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Abstract
The synthesis and spectroscopic characterization of diorganotin(IV) bis(difluorobenzoates) [F2C6H3COO]2SnR2 [type a] and bis[diorgano(difluorobenzoato)tin(IV)] oxides {[(F2C6H3COO)R2Sn]2O}2 [type b] are described. An X-ray structure study has revealed compound 3b, {[(2,6-F2C6H3COO)(n-C4H9)2Sn]2O}2, to be dimeric and built around a planar Sn2O2 ring. The crystals are triclinic P1BAR with the cell dimensions a=11.935(13), b=12.3675(14), c=12.974 angstrom, alpha=92.89(8), beta=84.32(7), gamma=67.49(9)-degrees; Z=1, with the dimer being centro-symmetric. Selected compounds have been tested in vitro against two human tumour cell lines, MCF-7 (a mammary tumour) and WiDr (a colon carcinoma), and exhibit promising cytotoxicities.
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Gielen, M., Biesemans, M., Elkhloufi, A., Meunierpiret, J., Kayser, F., & Willem, R. (1993). Diorganotin Difluorobenzoates - Synthesis, Spectroscopic Characterization and In-vitro Antitumor-activity - X-ray Structure Determination of Bis[di-n-butyl(2,6-difluorobenzoato)tin] Oxide. Journal of Fluorine Chemistry, 64(3), 279-291. https://doi.org/10.1016/S0022-1139(00)80561-8 (Original work published 1993)