Clinically unexpected cyclosporine levels using the ACMIA method on the RXL dimension analyser

Morelle, Johann;Wallemacq, Pierre;Van Caeneghem, Olivier;Goffin, Eric
(2011) Nephrology, Dialysis, Transplantation — Vol. 26, n° 4, p. 1428-1431 (2011)

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Abstract
Safe use of cyclosporine (CsA) in solid organ transplantation relies on regular whole-blood drug monitoring. Several promising immmunoassays, e.g. the antibody-conjugated magnetic immunoassay (ACMIA) method, were developed and commercialized during recent years to compete with liquid chromatography coupled to tandem mass spectrometry, which remains the reference method but is labor-intensive. We describe the occurrence of interference in the monitoring of whole-blood CsA after transplantation when using the ACMIA method and discuss the potential mechanisms involved in such interference. Clinically unexpected results of whole-blood CsA require immediate reassessment by another technique to prevent the risk of CsA underdosage and graft rejection.
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Morelle, J., Wallemacq, P., Van Caeneghem, O., & Goffin, E. (2011). Clinically unexpected cyclosporine levels using the ACMIA method on the RXL dimension analyser. Nephrology, Dialysis, Transplantation, 26(4), 1428-1431. https://doi.org/10.1093/ndt/gfr002 (Original work published 2011)