Methods and compositions for increasing stress tolerance of cells and organisms
(2023)
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2023BHBrevetWO2023161266A140.pdf
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- Authors
- Abstract
- The present application provides an in vitro method for incrasing tolerance of a cell to a stress factor, such as radiation, qherein said method comprises genetically engineering the cell to express a specific DNA ligase or a biologically active fragment thereof. Also genetically engineered cells that express the specific DNA ligase or a biologically active fragment thereof are provided, as well as recombinant polynucleotides comprising a polynucleotide that encodes the specific DNA ligase or a biologically active fragment thereof. Further, the genetically engineered cells are provided for use as a medicament or in a pharmaceutical composition. Finally, also method of using the genetically engineered cells in an environment characterized by radiation that is higher than terrestrial background is provided.
- Affiliations
Citations
Van Doninck, K., Nicolas, E., & Hallet, B. (2023). Methods and compositions for increasing stress tolerance of cells and organisms (Patent No. 22.02.2022). https://hdl.handle.net/2078.5/29601