sTREM-1 is a specific biomarker of TREM-1 pathway activation.

Jolly, Lucie; Carrasco, Kévin; Salcedo-Magguilli, Margarita; Garaud, Jean-Jacques; Lambden, Simon; van der Poll, Tom; Mebazaa, Alexandre; Laterre, Pierre-François; Gibot, Sebastien; Boufenzer, Amir; Derive, Marc

doi:10.1038/s41423-021-00733-5

sTREM-1 is a specific biomarker of TREM-1 pathway activation.

Jolly, Lucie

;

Carrasco, Kévin

;

Salcedo-Magguilli, Margarita

;

Garaud, Jean-Jacques

;

Derive, Marc

;et.al.

(2021) Cellular & Molecular Immunology — Vol. 18, n° 8, p. 2054-2056 (2021)

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Authors

Jolly, Lucie
Author
Carrasco, Kévin
Author
Salcedo-Magguilli, Margarita
Author
Garaud, Jean-Jacques
Author
Laterre, Pierre-FrançoisUCLouvain
Author
Derive, Marc
Author

Abstract

TREM-1 (triggering receptor expressed on myeloid cells-1) is a transmembrane receptor expressed by innate immune cells, including endothelial cells and platelets. TREM-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors (TLRs) to amplify the inflammatory responses to pathogens, thus promoting sepsis-induced immune dysregulation and organ dysfunction. [...]

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Jolly, L., Carrasco, K., Salcedo-Magguilli, M., Garaud, J.-J., Lambden, S., van der Poll, T., Mebazaa, A., Laterre, P.-F., Gibot, S., Boufenzer, A., & Derive, M. (2021). sTREM-1 is a specific biomarker of TREM-1 pathway activation. Cellular & Molecular Immunology, 18(8), 2054-2056. https://doi.org/10.1038/s41423-021-00733-5 (Original work published 2021)