Sir, Shunt-associated fungal infections are currently treated with systemic antifungal therapy and shunt replacement, as fungi inside the lumen form a biofilm in which microorganisms are protected from antifungal therapy. This is the reason why CSF cultures may remain positive despite optimal therapy. [...]
Affiliations
Bambino Gesù Children’s Hospital – (Italy) RomeDepartment of Medical and Surgical Neonatology
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Auriti, C., Piersigilli, F., Ronchetti, M. P., Campi, F., Amante, P. G., Falcone, M., & Goffredo, B. M. (2016). Shunt lock therapy with micafungin to treat shunt-associated Candida albicans meningitis in an infant. Journal of Antimicrobial Chemotherapy, 71(7), 2060-2061. https://doi.org/10.1093/jac/dkw072 (Original work published 2016)