Apoptosis induced by aminoglycosides in LLC-PK1 cells : comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation

Denamur, Sophie;Van Bambeke, Françoise;Mingeot-Leclercq, Marie-Paule;Tulkens, Paul M.
(2008) Antimicrobial Agents and Chemotherapy — Vol. 52, n° 6, p. 2236-2238 (2008)

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Authors
  • Denamur, SophieUCLouvain
    Author
  • Van Bambeke, Françoiseorcid-logoUCLouvain
    Author
  • Mingeot-Leclercq, Marie-PauleUCLouvain
    Author
  • Tulkens, Paul M.UCLouvain
    Author
Abstract
Aminoglycosides were compared for apoptosis induction (DAPI staining, activation of caspase 3) in renal LLC-PK1 cells. Amikacin caused less apoptosis than gentamicin in incubated cells. In electroporated cells, neomycin B and gentamicin caused apoptosis in the 0.06-0.1 mM range, isepamicin required larger concentrations (0.2 mM), and amikacin was without effect.
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Denamur, S., Van Bambeke, F., Mingeot-Leclercq, M.-P., & Tulkens, P. M. (2008). Apoptosis induced by aminoglycosides in LLC-PK1 cells : comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation. Antimicrobial Agents and Chemotherapy, 52(6), 2236-2238. https://doi.org/10.1128/AAC.01680-07 (Original work published 2008)