The necessary and sufficient condition to record brain responses to signals ascending through C-fibers seems to be avoidance of concomitant activation of Adelta-fibers. Several explanations are offered in the literature. One more is added, based on the phenomenon of post-event desynchronisation. Four methods, having in common the ability to selectively activate C-fiber afferents, are currently used to obtain ultralate-laser evoked potentials (LEPs) in a reliable way and with the appropriate latency. Exception made for the difference in latency, mainly due to the difference in peripheral conduction time, morphology and dynamic topography of the ultralate-LEPs (C-fibers), are similar to the late-LEPs (Adelta-fibers). These results suggest that both pathways have common cortical generators.
Plaghki, L., & Mouraux, A. (2002). Brain responses to signals ascending through C-fibers. International Congress Series, 1232, 181-192. https://doi.org/10.1016/S0531-5131(01)00809-3 (Original work published 2002)